The scalability of measurement and perturbation still largely constrains our understanding of fundamental biology. To overcome these challenges, we are developing predictive AI/ML models and high-throughput in silico screen technologies that can propel our research in gene regulation and cell fate engineering at scale. We expect these technological innovations to be the engine for fundamental cellular and molecular discoveries, thus unlocking novel approaches for manipulating cell fate and function. Read More

The hierarchical organization of the genome controls gene expression. We investigate how various regulatory components, such as transcription factors, DNA sequence features, epigenetic modifications, and non-coding RNAs, determine the states of the genome and orchestrate the precise regulation of genes, particularly during cell fate transitions. Read More

By studying the genome, we seek to uncover the fundamental mechanisms and principles that govern cell fate and function, state transitions, and their communications and homeostasis within tissue. Ultimately, we aim to develop scalable approaches for manipulating cell fate and function, paving the way for solving regeneration and aging challenges. Read More

The curiosity for development and evolution fuels our discoveries in fundamental biology and technological innovation. We combine interdisciplinary approaches to understand the genetic and molecular mechanisms underlying unique evolutionary traits, and how these mechanisms may inspire bioengineering and human medicine. Read More